[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: https://doi.org/10.29090/psa.2018.01.001Pharm Sci Asia 2018; 45(1), 1-12
 

Preparation of nanoemulsions by phase inversion temperature (PIT)

A. Jintapattanakit

- Department of Pharmacy and Center of Excellence in Innovative Drug Delivery and Nanomedicine, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.


Nowadays, there is an increasing interest in the utilization of nanoemulsions in many industries, such as pharmaceuticals, food and beverage, cosmetics and agrochemicals because of a number of potential advantages over conventional emulsions (i.e., increased bioavailability, enhanced long-term stability and high optical clarity) and microemulsions (i.e., relatively low amount of surfactant used). The productions of nanoemulsions are typically divided into high-energy and low-energy emulsification methods. High-energy methods involve the use of mechanical devices to break up particles into smaller sizes. In contrast, low-energy methods divert the intrinsic physicochemical properties of surfactants, co-surfactants and excipients in the formulation, leading to the generation of emulsion droplets in the nanometric range. Owing to the advantages of low-energy methods (i.e., low cost and ease of implementation), there is considerable interest in the productions of nanoemulsions using low-energy methods, namely spontaneous emulsification, phase inversion composition, and phase inversion temperature (PIT). Among these, the PIT method is the most widely used in industry and has evidenced the progress in the knowledge of the factors leading to nanoemulsions with minimum size and low PDI. In this review, the principle of the PIT method is presented. The major factors influencing nanoemulsion formation using the PIT method and its applications to other lipid-based nanocarriers are reviewed


Keyword:

Nanoemulsions; Phase inversion temperature; Low energy emulsification; Non-ionic surfactant




Download full paper (PDF File size: 822.13 KB.)





Vol.45
No.4
October - December 2018

See other volume

 


Vol.45
No.3
July - September 2018

See other volume

 


Vol.45
No.2
April - June 2018

See other volume

 


Vol.45
No.1
January - March 2018

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.