[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 33(1),

Acute and Subacute Toxicities of the Ethanol Extract from the Fruits of Terminalia belerica (Gaertn.) Roxb.

S. Thanabhorn,* K. Jaijoy, S. Thamaree and K. Ingkaninan


The study was carried out to evaluate acute and subacute toxicities of the ethanol extract from Terminalia belerica (Gaertn.) Roxb. A single oral administration of the ethanol extract at a dose of 5,000 mg/kg did not produce signs of toxicity, behavioral changes, mortality and differences on gross appearance of internal organs. In the subacute toxicity, all rats were received a repeated oral dose of 1,000 mg/kg of the ethanol extract over 14 days. The satellite group was given the ethanol extract in the same period but kept for further 14 days without dosing in order to detect the delayed effects or reversibility of toxic effects. The results showed that the extract did not cause changes in terms of general behaviors, mortality, weight gain, hematological or clinical blood chemistry parameters. The results of gross and histological examinations showed normal appearance of the internal organs when compared to those of the control group.


acute toxicity, subacute toxicity, Terminalia belerica, Ethanol Extract

Download full paper (PDF File size: 116.47 KB.)


See other volume


Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
All Volumes & Issues
Submit Online
Contact us
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register

Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.