[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2021.03.20.197Pharm Sci Asia 2021; 48(3), 291-299
 

Optimized chloroquine phosphate dosage regimens for early virological clearance of severe acute respiratory syndrome coronavirus 2 using Monte Carlo simulation

Nattapong Tidwong1, Baralee Punyawudho1, Pannee Leelawattanachai2, Suwida Tangtrakultham3, Pitchaya Dilokpattanamongkol3, Taniya Paiboonvong4, Supatat Chumnumwat3, Preecha Montakantikul3*

1 Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand
2 Department of Pharmacy, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
3 Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
4 Department of Pharmacy Practice, College of Pharmacy, Rangsit University, Pathum Thani, Thailand


Chloroquine (CQ) exhibited promising in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the optimal dosage regimens remain unknown. Our objective was to explore the optimal chloroquine phosphate (CQP) dosage regimens for early achievement of virological clearance within 48-72 hours to diminish in-hospital transmission to front-line healthcare workers. A 10,000-subject Monte Carlo simulation was performed to calculate both probability of efficacy and safety attainment (PTA) using pharmacokinetic (PK) parameters obtained from the published population PK study. Dosage regimens that early achieved PTA of efficacy (PTAeff) ≥90% within 48-72 hours, while maintained PTA of toxicity (PTAtox) ≤1% were considered optimal. For the previously proposed regimens in published guidelines and clinical studies, all dosage regimens could not achieve ≥90% PTAeff, except one with the highest dosage regimen. Our simulations suggested that large amount of loading dose was required for the early achievement. We designed three dosage regimens containing high loading dose (2-3 gram per day), which early achieved ≥90% PTAeff within 48-72 hours, while also maintained ≤1% PTAtox throughout the treatment course. Further clinical studies are needed to prove the efficacy and safety of our designed regimens.


Keyword:

Chloroquine; Monte Carlo; Pharmacokinetics; SARS-CoV-2; COVID-19




Download full paper (PDF File size: 1,190.90 KB.)





Vol.48
No.6
November-December 2021

See other volume

 


Vol.48
No.5
September - October 2021

See other volume

 


Vol.48
No.4
July - August 2021

See other volume

 


Vol.48
No.3
May - June 2021

See other volume

 


Vol.48
No.2
March - April 2021

See other volume

 


Vol.48
No.1
January - February 2021

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.