| DOI: 10.29090/psa.2021.06.21.071 | Pharm Sci Asia 2021; 48(6), 498-505 |
A mechanistic review of plumbagin effects againts diabetes and obesityNurfitri Bustamam1, Adelina Simamora2,3*
1 Department of Physiology, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia
2
Department of Biochemistry, Faculty of Medicine and Health Sciences, Krida Wacana Christian University, Jakarta, Indonesia
3
Centre for Enzyme Research in Health and Diseases, Krida Wacana Christian University, Jakarta, Indonesia
Plumbagin, a plant-derived metabolite, is a naphthoquinone derivative which has been studied for its diverse pharmacological effects including antidiabetic and anti-obesity effects. The present review focusses on reports concerning the effects of plumbagin on diabetes and obesity, and its mechanisms underlying these effects. Plumbagin exerts its antidiabetic effect by modulating key enzymes in glycolysis including α-glucosidase, hexokinase, and aldose reductase, and in gluconeogenesis such as glucose-6-phosphatase and fructose-1,6-biphosphatase. In addition, plumbagin stimulates glucose uptake in skeletal muscle cells by increasing GLUT4 translocation. Plumbagin regulates lipid metabolisms, by inhibiting pancreatic lipase, a lipolytic enzyme. Further, its effect on lipolysis is indicated by an increase in hepatic peroxisome proliferator-activated receptor alpha (PPARα). Regulation of lipogenesis is observed with decrease in sterol regulatory element binding (SREB) in the liver. More mechanistic studies are in need to provide support for the development of plumbagin as a pharmacological-therapeutics for diabetes and obesity.
Keyword:
Antidiabetic, Anti-obesity, Antioxidant, Enzymes, Glycolysis, Lipid-lowering, Plumbagin
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