[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 38(2),
 

Chemometrics-Assisted UV Spectrophotometric Method for Determination of Acetaminophen and Chlorzoxazone in Tablets

C.M. Phechkrajang*, S. Sribunruang, A. Thitipong, S. Jarusintanakorn, L. Sratthaphut, D. Nacapricha, and P Wilaira,

-


Chemometrics-assisted spectrophotometric approaches, principle component regression (PCR) and partial least square regression (PLS-1), were employed for determination of acetaminophen and chlorzoxazone in tablets. Two sets of standards mixtures, calibration set and test set, were prepared. The set of calibration mixtures were created by using a central composite design (CCD). The UV absorbance spectra of the resulted samples were subjected to partial least square regression (PLS-1) and principal component regression (PCR). The optimum regression models were used to determine the test set solutions for validation the models. An HPLC method was developed and also employed for comparison. The developed HPLC method, PLS-1 and PCR models were used to determine acetaminophen and chlorzoxazone in tablets. The determination results showed that the data obtained from PLS-1 and PCR models were not significantly different with those obtained from HPLC method at 95% confidence limit.


Keyword:

Chemometrics, PCR, PLS-1, Acetaminophen, Chlorzoxazone




Download full paper (PDF File size: 268.91 KB.)





Vol.38
No.3-4
July - December 2011

See other volume

 


Vol.38
No.1-2
January - June 2011

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.