[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 30(2),
 

Amides from Natural Acids against Oxidative Stress

Opa Vajragupta, Maleeruk Utsintong, Penchom Peungvicha, Hiroshi Watanabe

-


In searching for potent radical scavenging agents, a series of phenolic amides (1-4) were designed and synthesized. Four new amides were tested for the inhibitory action against lipid peroxidation using thiobarbituric acid method. All of the amides inhibited lipid peroxidation more than their corresponding acids. Ferulic amide 1 was the most active with IC50 of 19.92 uM. Investigation of the neuroprotection activity in NG 108-15 cells against H2O2 induced oxidative stress was performed. All new amides were able to reduce the number of cell deaths. Ferulic amide 1 was the most potent, showing significant effect at 1 nM (37.41% survival). The results indicated that, as proposed, the radical scavenging ability of the new amides was more potent than the corresponding acids. © All right reserved


Keyword:

Natural Acids ,Amides,Oxidative Stress ,radical scavenging agents,thiobarbituric acid , neuroprotection ,Ferulic amide








Vol.30
No.3
September-December 2003

See other volume

 


Vol.30
No.2
May-August 2003

See other volume

 


Vol.30
No.1
January-April 2003

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.