[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 29(1),
 

Biochemical Properties of Protiens Isolated from Mirabilis jalapa.

Wichet Leelamanit, Pongsakorn lertkunakorn, Sumalee Prapatrkul, Rith Watthanachaiyingcharoen, Omboon Luanrat, Nongluck Ruangwises, Prapan Suppakpatana

-


The seed powder of Mirabilis jalapa (four - o’ clock) is traditionally used for the treatment of microbial infection. Several reports also indicated that proteins isolated from the ripe seeds of Mirabilis species showed both antifungal and antibacterial activities. The aim of this study is to characterize the biochemical properties of crude proteins extracted from the mature seeds of Mirabilis jalapa. SDS- PAGE analysis showed three major bands of molecular weight of approximately 31, 24.5 and 13 kDa that were proved to be glycoproteins. The antibacterial activity of crude proteins was tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhimurium and was only active against B. subtilis at protein concentration of 0.37 mg/disc. Interestingly, the proteins exhibited potent anticancer activity to permanent cell lines L929 (mouse fibroblasts). The cytotoxicity tested with mosquito larvae of Aedes aegypti and Artemia salina (brine shrimp) was also investigated


Keyword:

Biochemical Properties , Mirabilis jalapa. , antifungal ,antibacterial,SDS- PAGE ,Staphylococcus aureus,Bacillus subtilis, Escherichia coli ,Salmonella typhimurium








Vol.29
No.3-4
September-December 2002

See other volume

 


Vol.29
No.1-2
January-August 2002

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.