| DOI: 10.29090/psa.2020.04.019.0072 | Pharm Sci Asia 2020; 47(4), 378-386 |
In vitro activity of biapenem and comparators against multidrug-resistant and carbapenem-resistant Acinetobacter baumannii isolated from tertiary care hospitals in ThailandJantana Houngsaitong1,
Preecha Montakantikul1,
Taniya Paiboonwong1,
Mullika Chomnawang2,
Piyatip Khuntayaporn2,
Suvatna Chulavatnatol1*
1 Department of Pharmacy, Faculty of Pharmacy,
Mahidol University, Bangkok, Thailand
2
Department of Microbiology, Faculty of
Pharmacy, Mahidol University, Bangkok,
Thailand
Acinetobacter baumannii is one of nosocomial pathogen which emerges as multidrug-resistance worldwide. Multidrug-resistant A. baumannii (MDRAB) and carbapenem-resistant A. baumannii (CRAB) are highly concerned due to limitation of therapeutic options. Antibacterial activity of biapenem was explored in order to overcome bacterial resistance. A total of 412 A. baumannii clinical isolates from 13 tertiary care hospitals in Thailand were collected. MIC values of biapenem and comparators; imipenem, meropenem, colistin, sulbactam, ciprofloxacin ceftazidime and fosfomycin sodium, were determined by broth microdilution method in accordance with the Clinical and Laboratory Standards Institute (CLSI) guidelines (2016). In total, 320 isolates (77.67%) were MDRAB and 328 isolates (79.61%) were CRAB while 58 isolates (14.07%) were colistin-resistant AB. A. baumannii showed widespread resistance to ceftazidime, ciprofloxacin and carbapenems in more than 90% of the strains; resistance to sulbactam, fosfomycin, and colistin were 85%, 60%, and 15% respectively. By comparison among carbapenems, biapenem showed MIC50/90 of 16/32 which were at least 2 folds lower than imipenem and meropenem (MIC50/90; 32/128, 32/64, respectively). In addition, 15% of imipenem and meropenem-resistant A. baumannii were susceptible to biapenem. Also, 19% of colistin-resistant A. baumannii were susceptible to biapenem. Although more than 90% of MDRAB and CRAB were resistant to carbapenems, biapenem showed a good activity over other carbapenems. This drug might be a therapeutic option mono or combination therapy besides other antimicrobial agents.
Keyword:
Biapenem; Multidrug-resistant A. Baumannii; Carbapenem-resistant A. Baumannii; Thailand
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