Bioactive Flavonoids and Alkaloids from Anomianthus dulcis (Dunal) J. Sinclair Stem BarkL. Ubonopas, P. Wongsinkongman, W. Chuakul, K. Suwanborirux, K.H. Lee, and N. Soonthornchareonnon*
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Three flavonoids (1, 2, 3) and two oxoaporphine alkaloids (4, 5) were isolated from Anomianthus dulcis stem barks. Structural elucidations of these compounds were established by spectroscopic data, as well as compared with literature data. Among them, liriodenine (5), 9-methoxyliriodenine (4) and (2S)-5-hydroxy-6,7-dimethoxyflavanone (1) exhibited selectively potent cytotoxicity against human small cell lung cancer call line (NCI-H187) with IC50 values at 1.02, 1.28 and 1.73 μg/ml, respectively. (2S)-5-hydroxy-7,8-dimethoxyflavanone (2), (1) and (5) were weakly active against human nasopharyngeal carcinoma cell line (KB) with IC50 values at 12.86, 15.45 and 13.45 μg/ml, respectively. While none of the isolated compounds showed cytotoxicity against breast cancer cell line (BC), (5) exhibited weakly active against BC with IC50 value at 14.57 μg/ml. Additionally, (5) showed strong anti-HSV-1 activity with IC50 value at 3.3 μg/ml. Compounds (5), (1) and (4) exhibited antimycobacterial activity with minimum inhibitory concentrations (MICs) of 100, 200, and 200 μg/ml, respectively. However, the isolated compounds possessed neither antiplasmodial nor anti-HIV activities.
Keyword:
Anomianthus dulcis, Flavonoids, Alkaloids
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