3D QSAR and Pharmacophore Identification Studies of Some Factor VIIa InhibitorsP. Choudhari*, M. Bhatia, S. Jadhav
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3D QSAR and pharmacophore identification studies plays vital role in development of new potent NCE’s. Various Coagulation factors are emerging target for the anticoagulant drug design. Here we report 3D QSAR and pharmacophore identification studies on 50 reported factor VIIa inhibitors. The QSAR equation and pharmacophore identification yielded that the presence of electron with drawing groups are important for factor VIIa inhibition.
Keyword:
3D QSAR, Pharmacophore, Factor VIIa, Vlife MDS 3.5
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