Antidiabetic Effects and in vitro Antioxidant Activity of Pseuderanthemum palatiferum (Nees) Radlk. ex Lindau Leaf Aqueous ExtractK. Chayarop, R. Temsiririrkkul*, P. Peungvicha, Y. Wongkrajang, W. Chuakul, S. Amnuoypol, and N. Ruangwises,
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Fresh leaves of Pseuderanthemum palatiferum (Nees) Radlk. ex Lindau which have therapeutic effects for various diseases including diabetes mellitus, have been widely used by Thai people who are seeking an alternative drug or complementary medicine. However, few studies of P. palatiferum biological activities have been reported. This study investigated the hypoglycemic effect of P. palatiferum leaf aqueous extract using an oral glucose tolerance test (OGTT) in normal rats and streptozotocin-nicotinamide-induced diabetic rats. A single oral administration of the aqueous extract at doses of 0.25 and 0.50 g/kg significantly decreased the blood glucose level in diabetic rats but not in normal rats. Both doses of the extract produced blood glucose lowering effect in diabetic rats after 30 minutes as well as glibenclamide, a hypoglycemic drug. Evaluation of the in vitro antioxidant activity demonstrated that the extract exhibited DPPH radical scavenging activity (IC50=221.14 ?g/ml), reducing activity, lipid peroxidation inhibitory effects, and protective effects against AAPH-induced hemolysis (HT5 =181.19 min). The total flavonoid content of the extract was 227.81 ? 10.70 mg/100g extract equivalent to kaempferol. The present investigation on antidiabetic and in vitro antioxidant effects of P. palatiferum leaf aqueous extract supports the use of P. palatiferum leaves as a complementary medicine for diabetes.
Keyword:
Pseuderanthemum palatiferum, Hoan-ngoc, Antidiabetic effects, Streptozotocin-nicotinamide-induced diabetic rats, Antioxidant activity
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