| DOI: 10.29090/psa.2020.03.019.0121 | Pharm Sci Asia 2020; 47(3), 205-220 |
Self-nanoemulsifying drug delivery systems (SNEDDS): an advancement technology for oral drug deliveryBoontida Morakul*
- Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
Nanotechnology is strongly accepted as the crucial approach in drug delivery that can influence the therapeutic performance of hydrophobic drugs. Self-nanoemulsifying drug delivery systems (SNEDDS) are one of the proven methods that can increase solubility and bioavailability of poorly water soluble drugs. SNEDDS are anhydrous homogenous liquid mixtures consisting of oil, surfactant, co-surfactant, and drugs, which spontaneously form o/w nanoemulsions when diluted with water under gentle agitation. SNEDDS provide several potential effects on oral drug delivery. This article presents an overview of SNEDDS along with their basics; such as, composition, preparation, characterization, potential effects associated with oral delivery, applications, commercially available products, advanced technology associated with SNEDDS, and trending.
Keyword:
Self-nanoemulsifying drug delivery systems; SNEDDS; Oral delivery; Nanoemulsions; Poor bioavailability
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