New leads of HIV-1 Integrase InhibitorsOpa Vajragupta and Preecha Boonchoong
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Following to reverse transcriptase (RT) and protease (PR), integrase (IN) has emerged as an attractive target for new anti-HIV-1 agents. IN was found to be promising candidate because of its necessary for viral life cycle and lack of IN homologous enzymes in the human host. Different classes of HIV-1 IN inhibitors have been reported, for example, aryl 1,3-diketo-containing compounds, hydrazide-containing compounds, styrylquinoline derivatives, L-chicoric acid analogues, thiazolothiazepine derivatives and other hydroxylated compounds including bis-catechols and curcumin. The important structural features that are essential for the inhibition of the integrase are pointed out in this review.
Keyword:
HIV-1 Integrase Inhibitors ,reverse transcriptase , protease ,integrase,anti-HIV-1 agents
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