| DOI: 10.29090/psa.2025.04.25.4820 | Pharm Sci Asia 2025; 52(4), 483-495 |
Design and development of bilastine-loaded self-nanoemulsifying drug delivery system (L-SNEDDS) for oral administration: Pharmacokinetic study
(In vivo analysis)Imdad H. Mukeri1, M. Sunitha Reddy2
- Centre for Pharmaceutical Sciences, University College of Engineering, Science & Technology, JNTU Hyderabad, Telangana, India.
Oral administration of a drug is the most common, ideal and preferred route of administration. The main problem of oral drug formulations is their low bioavailability arising from poor aqueous solubility of drugs. The study developed bilastine-loaded lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) in liquid formulations. The components used in the SNEDDS formulations included lipid (Capmul PG-NF), surfactant (Tween 40), and co-surfactant (Plurol Oleique). The optimized formulation was characterized through in-vivo analysis. The liquid-SNEDDS (L-SNEDDS) formulation [TP3PO1 (2:8)] demonstrated greater potential, showing a reduced particle size of 142.5nm, zeta potential −22.6mV, PDI 0.183, and a drug loading efficiency of 99.71 ± 0.67%, respectively. The optimized formulation of L-SNEDDS [TP3PO1 (2:8)] showed a stable nanoemulsion, and FT-IR studies indicated no interaction between the drug and excipients. The in-vivo pharmacokinetic study of the optimized bilastine-loaded L-SNEDDS formulation performed using albino rats (weight of single rat 250±25 g) showed that the area under the curve AUC0–24 for the optimized formulation [TP3PO1 (2:8)] was significantly higher 1129.45 ± 10.815 µg/mL/h compared to the drug suspension 179.96 ± 2.368 µg/mL/h. Cmax was also higher for TP3PO1 (2:8) 90.368 ± 2.596 µg/mL compared to the drug suspension 34.32 ± 2.31µg/mL. The plasma half-life (t1/2) of the optimized formulation TP3PO1 (2:8) was increased significantly 22.45 ± 0.251 hrs compared to that of the drug suspension 18.57 ± 0.312 hrs. Overall, a range of lipid-based SNEDDS liquid formulations was successfully developed and appears to be a promising alternative for improving the solubility of poorly water-soluble drugs and evaluating pharmacokinetic parameters.
Keyword:
Self-nanoemulsifying drug delivery system (SNEDDS); Capmul PG-NF; Tween 40; Plurol Oleique; Bilastine; Solubility enhancement; Pharmacokinetic study.
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