| DOI: 10.29090/psa.2025.04.25.3825 | Pharm Sci Asia 2025; 52(4), 460-470 |
Ethosomes : As promising nanocarriers for novel drug delivery systemShivam Singh*, Arpita Singh, Ritunja Singh, Anupama Maurya, Urmila Nishad, Priyanka Tyagi, Harshit Yadav
- Department of Pharmaceutics, SethVishambhar Nath Institute of Pharmacy, Dewa Road Lucknow
Ethosomes, a kind of vesicle, are microscopic structures that aid in the efficient delivery of drugs over the epidermal barrier by focusing their action on certain cells. Due to their unique composition and structural properties, ethosomes, which are innovative phospholipid vesicular carriers containing elevated concentrations of ethanol, provide efficient absorption and enhanced permeability through the skin. Pharmacosomes, which are drug-lipid complexes with improved drug dispersion and administration, are new drug delivery technologies being developed. Improved drug permeability and targeting are provided by sophisticated systems including aquasomes, cubosomes, and ethosomes, which increase the efficacy of drug delivery. Different techniques, including as the hot method, cold method, and dispersion approach, can be used to manufacture ethosomes, and each has an impact on the end product's properties. Ethosomes are a kind of lipid vesicle that show promise for drug delivery applications because they are flexible and enhance medication penetration into the circulation and deep skin layers. A comprehensive overview of drug delivery ethosomes, including their types, compositions, preparation methods, characterizations, marketed formulations, applications, and ultimately, future prospects, is also included in this article.
Keyword:
Vesicles; Ethosome; Ethanol; Penetration; Topical route; Transdermal delivery
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