| DOI: 10.29090/psa.2026.01.25.5040 | Pharm Sci Asia 2026; 53(1), 1-10 |
Antiplatelet, anticoagulant, and thrombolytic effect of Carica papaya L. leaf ethanol extract in the thrombosis mouse modelMartina Kurnia Rohmah1*, A’yunil Hisbiyah1, Amellya Octifani2
1 Department of Pharmacy, Faculty of Health Science, Universitas Anwar Medika, Sidoarjo, Indonesia
2 Department of Medical Laboratory, Faculty of Health Science, Universitas Anwar Medika, Sidoarjo, Indonesia
Cardiovascular diseases such as stroke and chronic ischemia are among the leading causes of death worldwide. The one factor that causes this disease is thrombosis. A thrombus blocks blood flow, reduces oxygen supply, and damages endothelial tissue and myocytes. Various anti-thrombotic drugs that have been used so far have several side effects, such as bleeding, thrombocytopenia, pain, and others. Carica papaya L. is a plant that affects antiplatelet, anticoagulant, and thrombolytic in vitro. This study aimed to determine the effect of antiplatelet, anticoagulant, and thrombolytic agents in vivo using the thrombosis mouse model. The research subjects were 24 mice divided into eight groups: normal control, negative control (thrombosis), positive control (clopidogrel, warfarin, and natto-kinase), Carica papaya L leaf ethanol extract (CPEE) 2, 20, and 200 mg/kg body weight. The treatment was given for 24 hours after thrombosis induction. The blood sample was taken to determine platelet aggregation inhibition, PT, APTT, and percent of thrombolysis. The study showed that the ethanol extract of Carica papaya leaf at 20 and 200 mg/kg BW significantly (p<0.05) differed from the negative control. Ethanol extract of Carica papaya L leaves at a dose of 200 mg/kg BW is the best dose to inhibit platelet aggregation, normalize PT and APTT after thrombosis induction, increase the percentage of thrombolysis and D-Dimer level in the thrombosis mouse model.
Keyword:
Anticoagulant; Antiplatelet; Carica papaya L; Leaf; Thrombolytic
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