| DOI: 10.29090/psa.2024.02.24.1651 | Pharm Sci Asia 2024; 51(2), 173-179 |
Comparative stability of imipenem and meropenem solutions for extended infusion administrationWasan Katip*, Chuleegone Sornsuvit, Purida Wientong
- Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand
The stability of antibiotic solutions is a critical factor influencing their efficacy during extended infusion administration. This study investigates and compares the stability of imipenem and meropenem solutions in 0.9% sodium chloride at two temperatures—25?C and 30?C—over a 6-hour period. Imipenem and meropenem solutions, each at a concentration of 10 mg/mL, were prepared and incubated, and samples were collected at various intervals. High-performance liquid chromatography (HPLC)was employed to analyze the remaining antibiotic concentrations. Statistical analyses, including t-tests, were conducted to assess stability at different time points and temperatures. Results revealed that, at 25?C, meropenem solutions maintained stability above 90% throughout the 6-hour duration, while imipenem solutions showed a significant decrease after 3 hours. At 30?C, meropenem solutions remained stable for 4 hours, whereas imipenem solutions rapidly declined below 90% within 1 hour. Comparison between the two antibiotics demonstrated that meropenem exhibited significantly higher stability at 4 and 6 hours at both temperatures (p<0.05). In conclusion, this study offers crucial insights into the stability profiles of imipenem and meropenem during extended infusion. Meropenem emerged as the preferred choice due to its superior stability, emphasizing the importance of temperature considerations in administration and the necessity for proper storage and handling to preserve antibiotic stability.
Keyword:
Imipenem, Meropenem, Stability, Extended Infusion, High-Performance Liquid Chromatography, Antibiotic Solutions
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