Hypolipidemic Effect of Extracts from Abelmoschus esculentus L. (Malvaceae) on Tyloxapol-Induced Hyperlipidemia in MiceT. Huynh Ngoc,* Q. Nguyen Ngoc, A. Tran T Van and N. Vo Phung
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Background: Abelmoschus esculentus L. (Malvaceae) has been used for a long time as a daily food in many countries because of its nourishing components. Extracts from A. esculentus are known to ameliorate not only hyperglycemia but also hyperlipidemia in diabetic mice induced by alloxan and streptozocin. However, its hypolipidemic activity has not yet been clearly studied. Objective: Hypolipidemic activity of the extracts from total plant by dichloromethan (AE1) and methanol (AE2), and from fruit by dichloromethane (AE3) and methanol (AE4) was studied and compared to that of simvastatin (Zocor?). Methods: Hyperlipidemia in mice was induced by single intra-peritoneal injection of 300 mg/kg of tyloxapol. Studied extracts were orally administered at dose equivalent to 30 g of dry extract/kg immediately after tyloxapol injection. Results: Cholesterol levels decreased 56.45%, 55.65%, 41.13%, 40.50% and 53.63%, respectively in groups orally administered AE1, AE2, AE3, AE4 and simvastatin as compared to the tyloxapol injected group. Triglyceride levels in treated groups had no significant difference as compared to simvastatin group except the AE4 treated group. Conclusion: A. esculentus could lower cholesterol and triglyceride levels in hyperlipidemic mice.
Keyword:
Abelmoschus esculentus, hyperlipidemia, simvastatin, tyloxapol, Malvaceae, cholesterol, triglyceride
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