| DOI: 10.29090/psa.2024.03.24.1630 | Pharm Sci Asia 2024; 51(3), 250-258 |
Exploring the Therapeutic Potential of an Herbal-Based Topical Cream in Psoriasis PatientsWantika Kruanamkam1, Pataweekorn Ketkomol1, Darunee Sertphon2, Pichit Boonkrong3, Thanvisith Charoenying4,*
1 Pharmacology and Toxicology Unit, Department of Medical Sciences, Faculty of Science, Rangsit University, Pathum Thani, Thailand
2
Department of Chemistry, Faculty of Science, Rangsit University, Pathum Thani, Thailand
3
College of Biomedical Engineering, Rangsit University, Thailand
4
Faculty of Allied Health Sciences, Pathumthani University, Pathum Thani, Thailand
This study investigates the therapeutic potential of an herbal-based topical cream for treating psoriasis, a chronic inflammatory skin condition that detrimentally affects patients' quality of life. The 8-week longitudinal cohort study evaluated the efficacy of a novel herbal topical cream, formulated with coconut oil, sesame oil, clove oil, mangosteen peel, turmeric rhizome, licorice root, and other plant extracts in 49 patients with psoriasis. Disease severity was quantified using the Psoriasis Area and Severity Index (PASI) at baseline, and at the 2nd, 4th, 6th, and 8th weeks. Additional assessments, including the Psoriasis Disability Index (PDI) and Dermatology Life Quality Index 0DLQI) were performed before and after the treatment period. PASI scores were analyzed using the Friedman test for repeated measures and pairwise Wilcoxon signed-rank test at a significance level of 0.05. Results demonstrated significant psoriasis remission, with noticeable efficacy observed by week 4 and sustained improvements throughout the 8-week trial (p<0.05). Likewise, participants reported improved well-being, as indicated by reduced PDI and DLQI scores across all aspects. These findings suggest that the formulated herbal cream provides a novel topical therapeutic option for psoriasis, whether as an alternative or adjuvant treatment, enhancing both disease severity and patient quality of life. Therefore, this herbal topical cream represents a viable and safe option for psoriasis management, potentially providing an effective alternative or adjunct to conventional therapies such as steroid creams and coal tar ointments
Keyword:
Cohort study; Herbal medicine; PASI score; Psoriasis; Therapeutic potential
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