| DOI: 10.29090/psa.2024.01.23.1110 | Pharm Sci Asia 2024; 51(1), 28-35 |
Investigation of banana peel powder in scopolamine induced neurobehavioral changes in zebrafish modelSweety Gupta1, Shivakumar Hugar1, Virupanagouda Police Patil1, Santosh Awasthi1, Leela Hugar2, Nanjappaiah Hanakuntimath1*
1 Department of Pharmacology, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur, Karnataka, India
2 Department of Pharmacology, Sri B.M. Patil Medical College, Hospital and Research Centre, Vijayapur, Karnataka, India
The present research work was intended to carry out the neuroprotective efficacy of banana peel powder (BPP) in scopolamine induced amnesia in zebrafish. The effect of BPP was assessed by Novel tank test, Y-Maze test and Color-biased appetite conditioning T-Maze test. In novel tank test, the different concentrations of BPP (12.5, 25 and 50 mg/L) showed dose dependent increase in the number of entries to top, time spent in top, latency to enter top and total distance travelled in tank whereas decrease in number of entries to bottom and time spent in bottom as compared to scopolamine control group. In Y-Maze test, BPP at various strengths exhibited dose dependent significant increase in number entries to novel arm, time spent in novel arm and total distance travelled in the maze as compared to scopolamine control group. The different concentrations of BPP showed significant decrease in acetylcholinesterase (AChE) and MDA content in brain homogenate of zebrafish as compared to scopolamine control group. In T-Maze test BPP at 12.5, 25 and 50 mg/L exhibited dose dependent significant increase in number of entries to green arm and time spent in green arm whereas significant decrease in number of entries to red arm and time spent in red arm as compared to scopolamine control group in dose dependent manner. The results obtained in this study conclude that, BPP could effectively improve memory impairments in a scopolamine induced zebrafish model of amnesia by enhancing the function of the behavioral response and antioxidant enzymes in the amnesic zebrafish model.
Keyword:
Neuroprotective, Novel Tank Test, AChE, MDA, Zebrafish
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