Acute and Subacute Toxicities of the Ethanol Extract from the Fruits of Terminalia belerica (Gaertn.) Roxb.S. Thanabhorn,* K. Jaijoy, S. Thamaree and K. Ingkaninan
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The study was carried out to evaluate acute and subacute toxicities of the ethanol extract from Terminalia belerica (Gaertn.) Roxb. A single oral administration of the ethanol extract at a dose of 5,000 mg/kg did not produce signs of toxicity, behavioral changes, mortality and differences on gross appearance of internal organs. In the subacute toxicity, all rats were received a repeated oral dose of 1,000 mg/kg of the ethanol extract over 14 days. The satellite group was given the ethanol extract in the same period but kept for further 14 days without dosing in order to detect the delayed effects or reversibility of toxic effects. The results showed that the extract did not cause changes in terms of general behaviors, mortality, weight gain, hematological or clinical blood chemistry parameters. The results of gross and histological examinations showed normal appearance of the internal organs when compared to those of the control group.
Keyword:
acute toxicity, subacute toxicity, Terminalia belerica, Ethanol Extract
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