Study of Oxaliplatin-based Chemotherapy-Induced Neurotoxicity in Colorectal Cancer Thai PatientsJ. Wutthikonsammakit, B. Chindavijak,* U. Chaikredkaew, W. Lausoontornsiri
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Oxaliplatin is known to cause neurotoxicity, especially peripheral neuropathy. To prevent such symptom, oxaliplatin is recommended to be administered in a prolonged infusion time. This was an observational study to determine the incidence of neurotoxicity in colorectal cancer Thai patients of the National Cancer Institute who received different infusion time of oxaliplatin. All patients were prospectively determined for neurotoxicity at each cycle of chemotherapy in which oxaliplatin was infused for 2-, 4-, and 6-hour per doctor’s order. The severity of symptoms was graded according to the Oxaliplatin-Specific Neurotoxicity Scale. At the last cycle, patients answered the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire to evaluate quality of life. Thirty two patients were enrolled and 75% were infused for 2-hour regimen. Motor neurotoxicity and sensory alteration were presented in almost all cycles. Incidence of increasing severity was found along the increasing cycle, and it was similar among the three groups of different infusion time. The median cumulative dose of oxaliplatin in the group without symptoms, grade 1, 2 and 3 neurotoxicity were 300, 468.8, 671.9, and 1,031.3 mg/m2, respectively (ranged from 112.5 to 937.5 mg/m2, 162.5 to 1,012.5 mg/m2, 150 to 975 mg/m2, and 812.5 to 1,125 mg/m2, respectively). Total scores of quality of life were good, higher than 70. It was concluded that oxaliplatin caused progressive neurotoxicity along the increasing cycle and there was a tendency that prolonged duration of infusion resulted in lower incidence of neurotoxicity.
Keyword:
oxaliplatin, neurotoxicity, colorectal cancer, quality of life.
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