| DOI: https://doi.org/10.14456/mujps.2015.14 | Pharm Sci Asia 2015; 42(3), 110-117 |
Hemostatic effect of n-hexane extracts of Jatropha curcas Linn leafP. Wongkrajang1, Nurlely2,7, S. Phornchirasilp2*, R. Temsiririrkkul3, S. Thongpraditchote4, N. Ruangwises5, A. Mitrevej6, R. Khammanit2, R. Hanyongyuth1
1 Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700 Thailand
2 Department of Pharmacology,
3 Department of Pharmaceutical Botany,
4 Department of Physiology,
5 Department of Pharmaceutical Chemistry,
6 Department of Manufacturing, Faculty of Pharmacy, Mahidol University, Bangkok, 10400 Thailand
7 Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia
The leaf extract of Jatropha curcas Linn has been widely investigated for its chemical and pharmacological properties. Methanolic extract and hexane extract of Jatropha curcas leaf has been demonstrated to exhibit antimicrobial, antiviral, antioxidant, anticancer, analgesic, anti-inflammatory, and wound healing properties. In this study, the hemostatic effect and the possible mechanism of n-hexane extract of Jatropha curcas Linn leaf was revealed through bleeding time, platelet function test, and coagulation test. It was found that n-hexane Jatropha curcas Linn leaf extract exhibited a significant decrease in bleeding time (P<0.05) Our study suggests the possible mechanism of n-hexane extract of Jatropha curcus Linn as an enhancer of platelet aggregation due to the activity of phorbol esters or phorbol ester derivatives. The safety and efficacy of this extract should be further investigated and verified prior to the development of tropical hemostasis products for inhibition of bleeding.
Keyword:
Jatropha curcas Linn, hemostasis, bleeding time, coagulation study, platelet function test, phorbol esters
Download full paper (PDF File size: 636.06 KB.)
|
