Clinically Monitoring and Evaluating Tobramycin Concentration at Cho Ray Hospital, Hochiminh City D.T. Dang Nguyen,1* M. Mai Phuong,1 T. Lu Lan1 and D. Phan Thi2
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Tobramycin has been primarily used in case of severe infections caused by gram negative bacteria. However, as an aminoglycoside antibiotic, tobramycin can cause nephrotoxicity and otoxicity. In addition, it is also an antibiotic with narrow therapeutic window. A prospective study was conducted on 30 patients to monitor the concentrations of tobramycin at peak and trough levels as well as renal function to evaluate the dosage and possibility of nephrotoxicity during treatment. Only 53.3% and 56.7% patients possessed tobramycin trough and peak concentrations, respectively within normal limits. No significant difference was found in trough and peak concentrations between 3rd and 9th doses. After five days of drug therapy, no significant influence on renal function was recorded. Trough concentrations seemed to exceed normal range (0.5-2 µg/ml) in those with low clearance creatinine before treatment as well as in those using tobramycin concomitantly with other medicines which can influence renal function. However, there must be larger studies to re-examine this judgement.
Keyword:
BUN, creatinine, intramuscular injection, tobramycin, Cho Ray
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