| DOI: 10.29090/psa.2026.03.26.2035 | Pharm Sci Asia 2026; 53(3), 409-418 |
Optimization of sodium alginate concentration in a raft-forming system for the targeted gastric delivery of ginger extractWorawut Kriangkrai 1,2, Nontakron Jaiya 1, Watcharin Meerod 1, Srisagul Sungthongjeen 1,2*
1 Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand
2 Research and Innovation Cluster for Natural Health Products, Naresuan University, Phitsanulok 65000, Thailand
Sodium alginate concentration is a critical parameter in developing effective raft-forming systems for gastric targeting. This study evaluated concentrations of 1–5% w/w to optimize gastroretentive delivery of 6-gingerol for Helicobacter pylori (H. pylori) treatment. Increasing alginate concentration significantly enhanced viscosity (30.36–2229.11 cP) and raft strength; the 3% w/w level was identified as optimal on the basis of rheological and floating properties. Gas-generating agents (sodium bicarbonate and calcium carbonate) were incorporated with this concentration to enable raft formation and sustained buoyancy. The optimized formulation containing 4.17 % w/w ginger extract appeared as a cloudy yellowish suspension (viscosity 840.96 cP), formed a stable raft within 10 s, and remained buoyant for more than 24 h. In vitro dissolution demonstrated a controlled, time-dependent release profile of 6-gingerol from the floating raft matrix. Stability evaluations conducted at 45?C and 75% relative humidity for 30 days demonstrated that despite minor decreases in physical strength and viscosity, the formulation maintained a consistent 6-gingerol release profile, confirming the robustness of the optimized system. The 3% w/w sodium alginate concentration therefore provided an optimal balance of viscosity, raft-forming capability, and flotation, enabling prolonged gastric residence and sustained 6-gingerol release with potential therapeutic benefit against H. pylori infection.
Keyword:
Zingiber officinale; 6-gingerol; Raft-forming suspension; Helicobacter pylori; Gastroretentive system; Sodium alginate
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