| DOI: 10.29090/psa.2025.03.24.3524 | Pharm Sci Asia 2025; 52(3), 433-441 |
Antioxidant potential of phytochemicals of Merremia Quinquefolia (L.) Hallier F. leaves extracts and their mitigation effect against imidacloprid-induced toxicity in zebrafish modelKritika Verma1, Surabhi Yadav1*, Kaneez Zahra2, Vikash Verma3
1 Department of Chemistry, Bipin Bihari College, Jhansi, Uttar Pradesh, 284001, India
2
Department of Zoology, Bipin Bihari College, Jhansi, Uttar Pradesh, 284001, India
3
Department of Chemistry, Dr. R. P. Richhariya Degree College, Barwasagar, Jhansi, Uttar Pradesh, 284201, India
In recent years, there has been growing interest in the role of free radicals and their impact on human health, particularly due to their ability to cause oxidative stress and cellular damage. Naturally occurring antioxidants, especially those derived from medicinal plants, are recognized for their potential to neutralize these harmful reactive oxygen species. Merremia quinquefolia (L.) Hallier f. (MQ) is one such medicinal plant, yet its phytochemical properties and antioxidant potential remain largely unexplored. This study aimed to investigate the phytochemical profile of MQ leaf extracts and quantify their total phenolic and antioxidant content. Furthermore, the study evaluated the protective effects of MQ leaf extract against imidacloprid-induced toxicity using Zebrafish as an in vivo model. The results of phytochemical screening confirmed the presence of alkaloids, flavonoids, phenolics, tannins, carbohydrates, and saponins. Among the extracts, the acetone fraction exhibited the highest phenolic and antioxidant content, while ethyl acetate showed the lowest. In vivo analysis demonstrated that the antioxidant properties of MQ extract played a significant role in mitigating oxidative stress induced by pesticide exposure. These findings support the potential therapeutic application of MQ leaves as a natural antioxidant source for combating pesticide-related oxidative damage.
Keyword:
Merremia quinquefolia; Phytochemicals; Antioxidants; Zebrafish; Imidacloprid
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