| DOI: 10.29090/psa.2025.01.24.2072 | Pharm Sci Asia 2025; 52(1), 120-132 |
In Vitro Anti-Inflammatory Potential of Twelve Myanmar Medicinal Plant Extracts via Anti-Protein Denaturation and Membrane Stabilization EffectMya Thida1,*, Hay Mar Aung1, Thandar Aung2, Zar Ni Linn2, The Su Moe2
1 Cell Culture Laboratory, Department of Biotechnology Research, Ministry of Science and Technology, Kyaukse 05151, Myanmar
2
Pharmaceutical Research Laboratory, Department of Biotechnology Research, Ministry of Science and Technology, Kyaukse 05151, Myanmar
This study is conducted to investigate the anti-inflammatory potential in collected plant extracts. The cytotoxicity activity of the test sample was evaluated by hemolysis assay, and antioxidant potency was measured by radical scavenging assays and total phenolic and flavonoid contents examination. The anti-inflammatory activity of test samples was carried out by antiglycation, protein denaturation inhibition, proteinase inhibition, and membrane stabilization. The hemolysis effect of tested extracts expressed in a percent range of 5.38 ± 0.18 to 29.77 ± 1.47, representing non-cytotoxic activities. Tamarindus indica (leaf) and Croton oblongifolius showed significant radical scavenging effects and antiglycation potency. Most of the tested extracts had higher phenolic and flavonoid contents. In addition, tested extracts have a potential anti-protein denaturation effect. According to the results, Benincasa cerifera, Tamarindus indica (leaf), Croton obligifolius, and Rumex maritimus represented significant inhibition to protein denaturation action at all test inducers to compare against their standard group. Moreover, Tamarindus indica (leaf), Croton oblongifolius, and Rumex maritimus exhibited significantly higher membrane stabilization activities. Tamarindus indica (leaf), Croton oblongifolius, and Rumex maritimus demonstrated the protein and membrane stabilization effect with higher antioxidant potency. Therefore, these tested extracts could be used as therapeutic supplements in the treatment of chronic inflammatory diseases.
Keyword:
Anti-inflammatory; Antioxidant; Anti-protein denaturation; Cytotoxicity; Membrane stabilization.
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