| DOI: 10.29090/psa.2026.04.25.9031 | Pharm Sci Asia 2026; 53(4), 543-555 |
Design and evaluation of polymeric micelles to enhance piperine dissolutionAlasen Sembiring Milala1,3, Sutriyo1, Yahdiana Harahap2, Silvia Surini1*
1 Laboratory of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, 16424, Indonesia
2 Bioavailability/Bioequivalence Laboratory, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
3 Laboratory of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Surabaya, 60293, Indonesia
Piperine, a bioactive compound derived from pepper fruit, exhibits anticancer potential but suffers from poor aqueous solubility, which limits its therapeutic application. This study aimed to develop polymeric micelles to enhance piperine release. Micelles were prepared using the thin-film hydration method, and seven formulations were initially evaluated based on particle size, polydispersity index (PDI), zeta potential, morphology, and entrapment efficiency. Quantification of piperine was performed using a validated reversed-phase high-performance liquid chromatography (RP-HPLC) method. Selected formulations underwent further testing, including release studies at pH 1.2 and 6.8, and stability assessments at 30° C and 40° C under 75% relative humidity (RH). The optimal formulation (F4, piperine: total polymer = 1:12.5 w/w; P123:F127 = 2:1 w/w) exhibited a particle size of 26 nm, a PDI of 0.0382, a zeta potential of -6.20 mV, a spherical morphology, and an entrapment efficiency of 6.20%. Release study revealed a 5.75‑ fold and a 4.55‑ fold increase in piperine release at pH 1.2 and pH 6.8, respectively, compared to pure piperine suspension. Stability study showed 40% and 47% reductions in piperine content after 3 months at 30° C and 40° C, respectively. These findings demonstrate that polymeric micelles are a promising nanocarrier system for improving the release profile of piperine.
Keyword:
Polymeric micelles; Piperine; Release enhancement; Drug delivery; Pluronic
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