| DOI: 10.29090/psa.2025.01.24.2091 | Pharm Sci Asia 2025; 52(1), 110-119 |
Effects of Mimosa pudica Linn. Extract on Reducing Seizures, Memory Impairment, and Emotional Disorders in a Mouse Model of Temporal Lobe Epilepsy Induced by TrimethyltinHoang Hai Nguyen1, Quang Tuan Kiet Le1, Nguyen Minh Tho Ho1, Ngoc Phuc Nguyen1, Thanh Binh Nguyen2,3, Quynh Dieu Trinh4, Lam Truong Tuong1, Phi Hoang Yen Tran1, Huynh Nhu Mai1,*
1 University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh city, 700000, Vietnam
2
Thu Dau Mot University, Binh Duong, 820000, Vietnam
3
Pham Ngoc Thach University of Medicine, Ho Chi Minh city, 700000, Vietnam
4
Ton Duc Thang University, Ho Chi Minh city, 700000, Vietnam
Mimosa pudica Linn., commonly known as "Mắc cỡ" in Vietnam, is a medicinal plant with anti-inflammatory, antibacterial, anxiolytic, and antidepressant properties. Despite its potential, there is a limit to the amount of research on its effects on conditions such as seizures and associated emotional impairment, as well as memory impairment. This study aims to investigate the impact of improving memory and emotional impairment of the extract on the mice induced with trimethyltin (2.5 mg/kg, i.p.). Mimosa pudica Linn. was extracted with 96% ethanol at a ratio of 1:15 (w/v). Mice were divided into 5 groups: control group, disease group, positive control group receiving galantamine 10 mg/kg/day for memory and behavior test or carbamazepine 10 mg/kg/day for seizure score, and treatment groups receiving extract (200 mg/kg/day and 400 mg/kg/day). The effects of treatment were assessed using the Elevated Plus Maze (EPM) for emotional disorders; the Morris Water Maze (MWM) and the Novel Object Recognition (NOR) for memory improvement. Compared to the control group, the extract at both doses increased the number of entries and time mice spent in the open arm in the EPM. In the MWM model, the extract at both doses increased the time mice spent swimming in platform area and decreased the time mice needed to find the escape platform during training days. Mice receiving extract at both doses spent more time exploring the new object in NOR. In summary, the MP extract has the effects of reducing seizures, ameliorating emotional disorders and memory impairment in mice injected with trimethyltin.
Keyword:
Mimosa pudica Linn.; Trimethyltin; Seizures; Memory impairment
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