| DOI: 10.29090/psa.2025.04.25.3959 | Pharm Sci Asia 2025; 52(4), 442-459 |
Exploring an interplay between drug-polymer interactions and amorphous solid dispersion stability: A reviewHemant Arjun Kamble, Ganga Srinivasan
- M. Pharmacy (Pharmaceutics), VES College of Pharmacy, Mumbai, India
Amorphous solid dispersions (ASDs) represent a promising approach to enhancing the oral bioavailability of poorly water-soluble drugs by forming stable, highly soluble amorphous states. Despite their advantages, significant challenges remain due to the metastable nature of ASDs, which often requires the incorporation of additives to inhibit crystallisation. This article explores the intricate interactions between drugs and polymers within ASDs, focusing on hydrogen bonding, ionic interactions, van der Waals forces, and hydrophobic interactions, and their roles in maintaining drug solubility and stability. It highlights that the drug release mechanism is complex and varies with drug loading, transitioning from polymer-controlled to drug-controlled release. Characterisation techniques such as thermal analysis, spectroscopy, and microscopy provide insights into the interactions and stability of ASDs. Despite advances, challenges remain regarding the complexity of interactions and the long-term stability of ASDs, necessitating further research into optimal polymer selection, drug-polymer ratios, and processing techniques. This study emphasises the need for a deeper understanding of drug-polymer interplay and its implications for the rational design of effective ASD formulations to improve drug delivery systems.
Keyword:
Amorphous solid dispersion; Drug-Polymer interactions; Polymer selection; Physical stability
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