คำถาม
อยากทราบว่าsalbutamolและ terbutalineใช้ต่างกันอย่างไรค่ะ
คำตอบ
Salbutamol(albuterol) และ terbutaline เป็นยาในกลุ่ม beta2 adrenergic
agonist มีข้อแตกต่างกันดังนี้
• Pharmacologic and pharmacokinetic properties
agent beta2 potency1 route Onset
(minute) Duration
(hrs.) Pregnancy risk factor
albuterol 2 PO Within 30 4-8 C
Inh Within 5 3-6
terbutaline 4 PO 30 4-8 B
SC 5-15 1.5-4
Inh 5-30 3-6
1 Relative molar potency: 1 = most potent
• Adverse reactions (≥3%)1
Adverse reaction albuterol terbutaline
1. Cardiovascular
Palpitations
1-10
≤ 23
Tachycardia 1-10 1.3-3
BP changes/hypertension 1-5 1
Chest tightness/pain/discomfort, angina 3 1.3-1.5
PVCs, arrhythmias, skipped beats 4
2. CNS
Tremor
1-24.2
5-38
Dizziness/vertigo 1-7 1.3-10
Shakiness/nervousness/tension 1-20 5-31
Drowsiness 1 5-11.7
Hyperactive/hyperkinesias, excitement 1-20
Headache 2-22 7.8-10
Insomnia 1-11
3. GI
Nausea/vomiting
2-15
1.3-10
Heartburn/ GI distress/ disorder ≤ 5 10
Diarrhea 1
4. Respiratory
Cough
1-5
Bronchospasm 1-15.4
Throat dryness/ irritation, pharyngitis ≤ 6
1 Data pooled for all routes of administration, all age groups, from separate studies, and are not necessarily comparable.
2 = Report; no incidence given.
agonist มีข้อแตกต่างกันดังนี้
• Pharmacologic and pharmacokinetic properties
agent beta2 potency1 route Onset
(minute) Duration
(hrs.) Pregnancy risk factor
albuterol 2 PO Within 30 4-8 C
Inh Within 5 3-6
terbutaline 4 PO 30 4-8 B
SC 5-15 1.5-4
Inh 5-30 3-6
1 Relative molar potency: 1 = most potent
• Adverse reactions (≥3%)1
Adverse reaction albuterol terbutaline
1. Cardiovascular
Palpitations
1-10
≤ 23
Tachycardia 1-10 1.3-3
BP changes/hypertension 1-5 1
Chest tightness/pain/discomfort, angina 3 1.3-1.5
PVCs, arrhythmias, skipped beats 4
2. CNS
Tremor
1-24.2
5-38
Dizziness/vertigo 1-7 1.3-10
Shakiness/nervousness/tension 1-20 5-31
Drowsiness 1 5-11.7
Hyperactive/hyperkinesias, excitement 1-20
Headache 2-22 7.8-10
Insomnia 1-11
3. GI
Nausea/vomiting
2-15
1.3-10
Heartburn/ GI distress/ disorder ≤ 5 10
Diarrhea 1
4. Respiratory
Cough
1-5
Bronchospasm 1-15.4
Throat dryness/ irritation, pharyngitis ≤ 6
1 Data pooled for all routes of administration, all age groups, from separate studies, and are not necessarily comparable.
2 = Report; no incidence given.
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Drug facts and Comparisons Pocket Version, 7 th edition 2003
Drug Information Handbook 15th edition 2008
Drug facts and Comparisons Pocket Version, 7 th edition 2003
Drug Information Handbook 15th edition 2008